Job Title: PhD Cell Biologist – Stem Cell Research & Processing

Institution: Apeiron Research Center Location: Boulder, Colorado

About Apeiron Research Center: The Apeiron Research Center, located in the innovation-driven community of Boulder, Colorado, is dedicated to pioneering advancements in cellular and regenerative medicine. Our privately funded center is at the forefront of developing cutting-edge stem cell therapies and microvesicle-based interventions aimed at revolutionizing patient care and treatment paradigms.

Position Overview: We are currently seeking a highly skilled and motivated PhD-level Cell Biologist with expertise in stem cell biology, specifically focusing on human mesenchymal stem cells (hMSCs). The successful candidate will join our dynamic research team and play an integral role in advancing Apeiron’s cell therapy programs through rigorous laboratory work, protocol development, regulatory compliance, and quality assurance activities.

Responsibilities

Primary Responsibilities:

• Conduct and oversee the xeno-free culturing and expansion of human mesenchymal stem cells (hMSCs).

• Supervise and manage cryobanking activities, ensuring best practices for cell cryopreservation, storage, and re-animation.

• Perform regular sterility checks using advanced methodologies including qPCR to maintain the highest standards of cell culture purity and safety.

• Support the implementation and advancement of novel culturing techniques involving additional stem cell lines, 2D culturing methodologies, and microvesicle isolation and characterization.

• Lead optimization of laboratory workflow and processes to enhance efficiency and ensure regulatory compliance.

• Provide training and guidance to technical staff in best laboratory practices and cell culture techniques.

• Maintain detailed and accurate documentation in compliance with internal standards and regulatory requirements.

Secondary Responsibilities

• Contribute actively to the design and establishment of our new state-of-the-art laboratory facility, ensuring optimized conditions for cell culture and processing.

• Assist in preparation and submission of documents required for Institutional Review Board (IRB) processes and Investigational New Drug (IND) applications to regulatory bodies.

Qualifications

Required Qualifications:

• PhD in Cell Biology, Molecular Biology, Bioengineering, Biomedical Sciences, or closely related field.

• Demonstrable experience in human mesenchymal stem cell (hMSC) culturing, processing, and expansion in xeno-free conditions.

• Extensive hands-on experience with cryopreservation techniques, including cryofreezing protocols and successful re-animation of cells.

• Strong background in regulatory processes including familiarity with IRB documentation and IND submissions.

• Familiarity with FDA regulatory environment pertaining to cellular therapies and regenerative medicine.

• Proven ability to collaborate effectively in multidisciplinary teams and communicate scientific findings clearly.

Preferred Qualifications

• Prior experience working with additional stem cell types, including adipose-derived MSCs, and familiarity with isolation and characterization of microvesicles/exosomes.

• Proficiency with advanced sterility testing methodologies including quantitative PCR (qPCR).

• Proficiency with cell phenotyping and quantification via Flow Cytometry.

• Prior experience optimizing laboratory protocols and workflows, particularly in cleanroom environments and cGMP compliance.

• Previous experience in establishing or transitioning to new laboratory facilities.

Why Join Apeiron Research Center:

• Work in a collaborative, cutting-edge, environment dedicated to advancing regenerative medicine and transformative cellular therapies.

• Contribute directly to innovative projects with high translational potential.

• Access to state-of-the-art facilities and the vibrant, scientific community of Boulder.

• Competitive salary and comprehensive benefits package.

Application Process: Via the Link below, Interested candidates should submit a detailed curriculum vitae, a cover letter describing research interests and relevant experience, and contact information for three professional references.

Apeiron Research Center is an Equal Opportunity Employer committed to diversity, inclusion, and equality in the workplace.